Shandong Qidu Pharmaceutical Co.,Ltd.

Special warning and precautions for use:

Use cautiously if any of the following cases happen:

(1). If the patients with the diabetic is taking caplendus biguanides (especially Phenformin), it may inhibit the absorbance of lactic acid of liver, and lactic acid intoxication may happen. (2) The patient with edema companied with Sodium retention trend.  (3) Blood pressure may arise for the patients with hypertension. (4)  Cardiac insufficiency (5) The degradation speed of lactate step down for the patients with hepatic inadequacy, it may delay the speed of correcting acidosis.  (6) Hypoxia and shock, not enough tissue blood-supply, the metabolism of lactate is slow, it may be influential for the speed to correct acidosis. (7) With excessive drinking, Salicylism toxicosis, Itype glycogen deposition, lactic acidosis may happen. The product is not appropriate to correct the balance of acid and alkali.  (8) With diabetes mellitus ketosis, Acetyl acetic acid, (Beta) -hydroxybutyric acid and lactic acid all arise, and may accompany with circulation not good and organ blood-supply not enough, the degradation speed of lactic acid reduce. (9) The patients with renal inadequacy may accompany with water and sodium retention, it may raise the load of heart and blood vessel.

The product is forbidden to use for the following cases: (1) heart failure and acute pulmonary edema (2) cerebral edema (3) lactic acidosis is obvious (4) severe hepatic inadequacy (5) serious renal failure with oliguria or anuria

The following items should be examined before use: (1) blood pH or carbon dioxide combining power (2) the concentration of sodium, potassium, and calcium in the serum (3) check the renal function  (4) blood pressure  (5) cardiorespiratory function state such as edema, breath lessness, cyanosis, bellows rales, jugular engorge, liver-jugular regurgitation and so on. If necessarily, examine the venous pressure or central venous pressure.  (6) when the product is administered for the patients with hepatic inadequacy , you should make careful inspection momentarily.

Interaction with other medicinal products and other forms of Interactions:

When administered with other medicine (such as macrolide antibiotic, alkaloid, sulfanilamide group), pay attention to the incompatibility may happen because of pH value and ionic strength change. The product contains Ca⁺, precipitation may happen when mixed with the blood contain natrium citricum.

[Indications and Clinical use]: For adjusting body fluid, electrolyte and acid-base balance.

[Strength]: 500ml: 93.0%~107.0% Sodium Lactate and 95.0%~105.0% Sodium Chloride, Potassium Chloride, Calcium Chloride

Product Name: Sodium Lactate Ringer's Injection, Sodium Lactate Ringer's Infusion

Product Description: The product is a colorless clear liquid.

Strength: (1)500ml: Sodium Lactate (4g); Sodium Chloride (3g); Potassium Chloride (0.15g); Calcium Chloride (0.1g)

INN or Generic Name: Sodium Lactate Ringer's Injection

Pharmaceutical Dosage Form: injection

Packaging: butyl rubber stopper and aluminium cap, polypropylene bottle; Glass  bottle

Carton packing: 

100ml: 80PCS/CTN, 726 CTNS/20'FT, 1559 CTNS/40'FT, 1828 CTNS/40'HQ

Port: Any port (depends on requests)       Certificate: GMP

Exporting Region: Areas which GMP is applicable

Therapeutic indications

It is indicated to adjust the equilibrium of humour electrolyte acid and alkali, Used for metabolic acid toxicosis or dehydration caused by metabolic acid toxicosis.

Posology and method of administration

By phleboclysis the general dose for the adult is 500-1000ml/time, but the dose can be reduced or increased according to the avoirdupois and the age. The speed of administration is 300~500 ml/hour.

Contraindications:

Solutions containing lactate are NOT FOR USE IN THE TREATMENT OF LACTIC ACIDOSIS.

[Pregnancy and Lactation]

The administration may intensify edema or raise the blood pressure for the gravida have pregnancy toxinosis.

[Pediatric Use]

Calculate the dose according to the age and body weight

[Geratology]

For the old patients usually have insidious cardiac insufficiency or renal inadequacy, so it is must be used carefully.&a